教育經(jīng)歷

1997年8月- 2001年8月，肯塔基大學(xué)/University of Kentucky (USA)，Ph.D.（博士學(xué)位）

2001年10月- 2005年7月，威斯康星大學(xué)麥迪遜分校/University of Wisconsin-Madison (USA)，博士后

2005年8月- 2014年8月，新加坡國立大學(xué)/National University of Singapore，助理教授、副教授 (tenured associate professor)

2006年6月- 2014年8月，新加坡淡馬錫生命科學(xué)研究所/Temasek Life Sciences Laboratory，研究員 (Principal Investigator /PI)，Senior PI

2014年6月- 2020年9月，中國科學(xué)院上海生命科學(xué)研究院 /中科院分子植物科學(xué)卓越創(chuàng)新中心 上海植物逆境生物學(xué)研究中心，研究員

2020年10月- 至今，北京大學(xué)現(xiàn)代農(nóng)學(xué)院，教授（長聘）                          

研究方向

     利用分子、生化、遺傳及組學(xué)等手段，揭示內(nèi)源及環(huán)境信號（光周期、冬季低溫等）調(diào)控植物開花時間（flowering time）的分子與表觀遺傳機制。種子植物歷經(jīng)營養(yǎng)生長后轉(zhuǎn)換至生殖生長，其轉(zhuǎn)換時機（即成花轉(zhuǎn)變時間或開花時間）受多種內(nèi)在因子（如年齡、激素、營養(yǎng)代謝等）與外源環(huán)境因素（如日照長度變化、溫度等）的調(diào)控。這些因素通過多種遺傳途徑如光周期路徑、春化路徑、年齡路徑等，調(diào)控開花時間基因的表達，從而誘導(dǎo)植物開花。研究內(nèi)容：利用模式開花植物以及主糧作物小麥等，聚焦春化路徑及光周期路徑，闡明季節(jié)轉(zhuǎn)換調(diào)控越冬植物在春季開花的表觀遺傳機制；揭示基礎(chǔ)代謝（三羧酸循環(huán)、氮代謝等）調(diào)控植物環(huán)境響應(yīng)及開花時間的分子與表觀遺傳機制；利用基因編輯等生物技術(shù)，改良作物開花時間等農(nóng)藝性狀。

代表性成果

1.  Niu D, Gao Z, Cui B, Zhang Y & He Y. (2024) A molecular mechanism for embryonic resetting of winter memory and restoration of winter annual growth habit in wheat. Nature Plants, DOI: 10.1038/s41477-023-01596-6.

2.  Huang F, Luo X, Ou Y, Gao Z, Tang Q, Chu Z, Zhu X & He Y. (2023) Control of histone demethylation by nuclear-localized α-ketoglutarate dehydrogenase. Science, 381: eadf8822.

3.  Zhang Z, Luo X, Yang, Y & He Y. (2023) Cold induction of nuclear FRIGIDA condensation in Arabidopsis. Nature, 7969: E27-E32.

4.  Gao Z, Li Y, Ou Y, Yin M, Chen T, Zeng X, Li R & He Y. (2023) A pair of readers of bivalent chromatin mediate formation of Polycomb-based "memory of cold" in plants. Molecular Cell, 83: 1109-1124.

5.  Xu G, Tao Z & He Y. (2022) Embryonic reactivation of FLOWERING LOCUS C by ABSCISIC ACID-INSENSITIVE 3 establishes the vernalization requirement in each Arabidopsis generation. Plant Cell, 34: 2205-2221.

6.  Li Z, Luo X, Ou Y, Jiao H, Peng L, Fu X, Macho AP, Liu R & He Y. (2021) JASMONATE-ZIM DOMAIN proteins engage Polycomb chromatin modifiers to modulate Jasmonate signaling in Arabidopsis. Molecular Plant, 14: 732-747.

7.  Luo X, Ou Y, Li R & He Y. (2020) Maternal transmission of the epigenetic 'memory of winter cold' in Arabidopsis. Nature Plants, 6: 1211-1218.

8.  Tao Z, Hu H, Luo X, Jia B, Du J* & He Y.* (2019) Embryonic resetting of the parental vernalized state by two B3 domain transcription factors in Arabidopsis. Nature Plants, 5: 424-435.

9.  Luo X, Chen T, Zeng X, He D & He Y. (2019) Feedback regulation of FLC by FLOWERING LOCUS T (FT) and FD through a 5' FLC promoter region. Molecular Plant, 12: 285-288.

10.  Li Z, Fu X, Wang Y, Liu R & He Y. (2018) Polycomb-mediated gene silencing by the BAH-EMF1 complex in plants. Nature Genetics, 50: 1254-1261.

11. Li Z, Jiang D & He Y. (2018) FRIGIDA establishes a local chromosomal environment for FLOWERING LOCUS C mRNA production. Nature Plants, 4: 836-846. 

12. Z. Li, Y. Ou, J. Li & He Y. (2018) Brassinosteroid signaling recruits Histone 3 lysine-27 demethylation activity to FLOWERING LOCUS C chromatin to inhibit the floral transition in Arabidopsis. Molecular Plant, 11: 1135-1146.

13. Y. He & Li Z. (2018) Epigenetic environmental memories in plants: establishment, maintenance, and reprogramming. Trends in Genetics, 34: 856-866.

14. Z. Tao, L. Shen, X. Gu, Y. Wang, H. Yu & He Y. (2017) Embryonic epigenetic reprogramming by a pioneer transcription factor in plants. Nature, 551: 124-128.

15. Yuan W, Luo X, Li Z, Yang W, Wang Y, Liu R, Du J & He Y. (2016) A cis cold memory element and a trans epigenome reader mediate Polycomb silencing of FLC by vernalization in Arabidopsis. Nature Genetics, 48: 1527-1534.

16. Li Z, Jiang D, Fu X, Luo X, Liu R & He Y. (2016) Integration of histone methylations with RNA processing by the nuclear mRNA Cap Binding Complex. Nature Plants, 2: 16015.