個(gè)人簡(jiǎn)介

研究員，博士生導(dǎo)師，博雅青年學(xué)者。

教育經(jīng)歷

周岳于2010年畢業(yè)于北京生命科學(xué)研究所（NIBS）與蘭州大學(xué)，獲博士學(xué)位。2011年起，先后在美國(guó)梅奧醫(yī)學(xué)中心、德國(guó)馬克斯普朗克植物育種學(xué)研究所進(jìn)行博士后/博士后研究員工作。2018年9月入職北京大學(xué)現(xiàn)代農(nóng)學(xué)院，同時(shí)加入蛋白質(zhì)與植物基因研究國(guó)家重點(diǎn)實(shí)驗(yàn)室、北京大學(xué)-清華大學(xué)生命科學(xué)聯(lián)合中心（CLS）。

研究方向

周岳實(shí)驗(yàn)室致力于研究表觀遺傳調(diào)控在植物發(fā)育和植物對(duì)環(huán)境的響應(yīng)中的作用，通過(guò)跨學(xué)科的研究方法，利用遺傳學(xué)、基因組學(xué)、細(xì)胞生物學(xué)和生物化學(xué)等研究手段，重點(diǎn)研究植物染色體3D結(jié)構(gòu)的分子機(jī)理以及生物學(xué)功能。主要研究結(jié)果以第一作者發(fā)表在Nature Genetics，Genome Biology, PNAS，Plant Cell，Plant Physiology等刊物上。回到北大后，以通訊作者在Nature Communications, Plant Cell發(fā)表文章，揭示了植物染色體一級(jí)以及3D結(jié)構(gòu)的調(diào)控模式。

代表性成果

1.  Yin, X., Romero-Campero, F JM., Yang, M., Baile, F., Cao, Y., Shu, J., Luo, L., Wang, D., Sun, S., Yan, P., Gong, Z., Mo, X., Qin, G., Myriam, C#, Zhou, Y^#. (2023). Binding by the Polycomb complex component BMI1 and H2A monoubiquitination shape local and long-range interactions in the Arabidopsis genome. Plant Cell 35, 2484-2503. 10.1093/plcell/koad112.

2.  Yang, T.T., Wang, D.Y., Tian, G.M., Sun, L.H., Yang, M.Q., Yin, X.C., Xiao, J., Sheng, Y., Zhu, D.M., He, H., and Zhou, Y. (2022). Chromatin remodeling complexes regulate genome architecture in Arabidopsis. Plant Cell 34, 2638-2651. 10.1093/plcell/koac117.

3.  Wei, S.B., Li, X., Lu, Z.F., Zhang, H., Ye, X.Y., Zhou, Y.J., Li, J., Yan, Y.Y., Pei, H.C., Duan, F.Y., Wang D.Y., Song, C., Wang, P., Zhang, C., Shang, L.G., Zhou, Y., Yan, P., Zhao, M., Huang J.R., Bock, R., Qian, Q., Zhou W.B. (2022). A transcriptional regulator that boosts grain yields and shortens the growth duration of rice. Science 377, eabi8455. 10.1126/science.abi8455.

4.  Gao, Z., Zhou, Y., and He, Y. (2022). Molecular epigenetic mechanisms for the memory of temperature stresses in plants. J Genet Genomics 49, 991-1001. 10.1016/j.jgg.2022.07.004.

5.  Yin, X., Romero-Campero, F.J., de Los Reyes, P., Yan, P., Yang, J., Tian, G., Yang, X., Mo, X., Zhao, S., Calonje, M., and Zhou, Y. (2021). H2AK121ub in Arabidopsis associates with a less accessible chromatin state at transcriptional regulation hotspots. Nat Commun 12, 315. 10.1038/s41467-020-20614-1.

6.  Lan, J., Zhang, J., Yuan, R., Yu, H., An, F., Sun, L., Chen, H., Zhou, Y., Qian, W., He, H., and Qin, G. (2021). TCP Transcription Factors Suppress Cotyledon Trichomes by Impeding a Cell Differentiation-regulating Complex. Plant Physiol 186, 434-451. 10.1093/plphys/kiab053.

7.  Zhou, Y., Wang, Y., Krause, K., Yang, T., Dongus, J.A., Zhang, Y., and Turck, F. (2018). Telobox motifs recruit CLF/SWN-PRC2 for H3K27me3 deposition via TRB factors in Arabidopsis. Nat Genet 50, 638-644. 10.1038/s41588-018-0109-9.

8.  Xue, L., Klinnawee, L., Zhou, Y., Saridis, G., Vijayakumar, V., Brands, M., Dormann, P., Gigolashvili, T., Turck, F., and Bucher, M. (2018). AP2 transcription factor CBX1 with a specific function in symbiotic exchange of nutrients in mycorrhizal Lotus japonicus. Proc Natl Acad Sci U S A 115, E9239-E9246. 10.1073/pnas.1812275115.

9.  Cui, H., Qiu, J., Zhou, Y., Bhandari, D.D., Zhao, C., Bautor, J., and Parker, J.E. (2018). Antagonism of transcription factor MYC2 by EDS1/PAD4 complexes bolsters salicylic acid defense in Arabidopsis effector-triggered immunity. Mol Plant 11, 1053-1066. 10.1016/j.molp.2018.05.007.

10. Zhou, Y., Tergemina, E., Cui, H., Forderer, A., Hartwig, B., Velikkakam James, G., Schneeberger, K., and Turck, F. (2017). Ctf4-related protein recruits LHP1-PRC2 to maintain H3K27me3 levels in dividing cells in Arabidopsis thaliana. Proc Natl Acad Sci U S A 114, 4833-4838. 10.1073/pnas.1620955114.

11. Zhou, Y., Romero-Campero, F.J., Gomez-Zambrano, A., Turck, F., and Calonje, M. (2017). H2A monoubiquitination in Arabidopsis thaliana is generally independent of LHP1 and PRC2 activity. Genome Biol 18, 69. 10.1186/s13059-017-1197-z.

12. Merini, W., Romero-Campero, F.J., Gomez-Zambrano, A., Zhou, Y., Turck, F., and Calonje, M. (2017). The Arabidopsis Polycomb Repressive Complex 1 (PRC1) Components AtBMI1A, B, and C Impact Gene Networks throughout All Stages of Plant Development. Plant Physiol 173, 627-641. 10.1104/pp.16.01259.

13. Zhou, Y., Hartwig, B., James, G.V., Schneeberger, K., and Turck, F. (2016). Complementary Activities of TELOMERE REPEAT BINDING Proteins and Polycomb Group Complexes in Transcriptional Regulation of Target Genes. Plant Cell 28, 87-101. 10.1105/tpc.15.00787.

14. F?rderer, A., Zhou, Y., and Turck, F. (2016). The age of multiplexity: recruitment and interactions of Polycomb complexes in plants. Curr Opin Plant Biol 29, 169-178. 10.1016/j.pbi.2015.11.010.

15. Hu, J.-Y., Zhou, Y., He, F., Dong, X., Liu, L.-Y., Coupland, G., Turck, F., and de Meaux, J. (2014). miR824-Regulated AGAMOUS-LIKE16 Contributes to Flowering Time Repression in Arabidopsis. Plant Cell 26, 2024-2037. 10.1105/tpc.114.124685.

16. Zhou, Y., Zhang, J., Lin, H., Guo, G., and Guo, Y. (2010). MORPHEUS' MOLECULE1 is required to prevent aberrant RNA transcriptional read-through in Arabidopsis. Plant Physiol 154, 1272-1280. 10.1104/pp.110.162131.

17. Zhou, Y., Yang, Z., Guo, G., and Guo, Y. (2010). Microfilament dynamics is required for root growth under alkaline stress in Arabidopsis. J Integr Plant Biol 52, 952-958. 10.1111/j.1744-7909.2010.00981.x.