個(gè)人簡(jiǎn)介

2009.09 - 2015.06，四川農(nóng)業(yè)大學(xué)，Ph.D.（博士學(xué)位）

2012.11 - 2014.10，美國加州大學(xué)戴維斯分校（University of California, Davis），國家公派聯(lián)合培養(yǎng)博士

2015.01 - 2019.03，美國加州大學(xué)戴維斯分校（University of California, Davis），博士后

2019.04 – 至今，北京大學(xué)現(xiàn)代農(nóng)業(yè)研究院，研究員，課題組長（PI）

主要榮譽(yù)

2022年 國家級(jí)重點(diǎn)人才工程

2022年 山東省“泰山學(xué)者”青年專家

2020年 濰坊市“鳶都產(chǎn)業(yè)領(lǐng)軍人才”

研究工作與成果

     本實(shí)驗(yàn)室以小麥為研究對(duì)象，利用正向與反向遺傳學(xué)、轉(zhuǎn)錄組學(xué)、基因組學(xué)、分子和生化等方法解析小麥重要功能基因，特別是小麥真菌病害抗性基因。開展基因的定位、克隆和功能分析，并進(jìn)行小麥的遺傳改良和種質(zhì)創(chuàng)新。重點(diǎn)包括：1、小麥銹病抗性基因的挖掘與定位、關(guān)鍵抗病基因的克隆、抗病分子機(jī)制的研究；2、小麥產(chǎn)量、發(fā)育相關(guān)基因克隆，功能機(jī)制的研究；3、小麥種質(zhì)資源評(píng)價(jià)和小麥種質(zhì)創(chuàng)新。

     課題組已成功從小麥及其近緣種屬克隆到了7個(gè)抗銹病新基因，包括來自于擬斯貝爾托山羊草的Lr47，一粒小麥T. monococcum的Sr21、Sr60和Sr22b；來源于四倍體小麥的Sr13、Sr9a-9h和Yr15（參與）。兩個(gè)穗部發(fā)育相關(guān)基因HB2和WAPO-A1（參與）。此外，先后發(fā)掘定位了Sr60、SrTm4、SrTm5、SrKN、LrKP等多個(gè)新型抗病基因。在Nature Communications、PNAS、New Phytologist、Plant Biotechnology Journal等國際主流刊物上發(fā)表了SCI論文30余篇，獲批國家發(fā)明專利6項(xiàng)；主持國家、省、市科研項(xiàng)目6項(xiàng)，創(chuàng)制小麥新品系8份。

代表成果

(第一作者*；通訊作者#)

26. Li H*, Hua L*, Zhao S*, Hao M, … …, Wang X#, Chen S#. Cloning of the wheat leaf rust resistance gene Lr47 introgressed from Aegilops speltoides. Nature Communications, 2023, 14(1): 6072

25. Zhang J*, Nirmala J*, Chen S*, Jost M*, … …, Zhang P#, Rouse M#, Lagudah E#.  Single amino acid change can alter the specificity of the multi-allelic wheat stem rust resistance locus SR9. Nature Communications, 2023, 14: 7354

24. Liu Y, Hou S, Chen S. Kinase fusion proteins: intracellular R-proteins in plant immunity. Trends in Plant Science, 2023, TRPLSC2561

23. Wang X*, Li H*, Shen T, … …, Wang X, Qu X, Chen S#, Guo L#. A near-complete genome sequence of einkorn wheat provides insight into the evolution of wheat A subgenomes. Plant Communications, 2023, https://doi.org/10.1101/2023.05.07.539731

22. Wang J, Li H, Shen T, Lyu S, … …, Rouse M#, Chen S#. High-resolution genetic mapping and identification of candidate genes for the wheat stem rust resistance gene Sr8155B1. The Crop Journal, 2023, https://doi.org/10.1016/j.cj.2023.09.006

21. Chang C, Yang S, Zhang M, … …, Chen S, Xie C, Ni Z, Sun Q, Gou J#. Suppression of ZEAXANTHIN EPOXIDASE 1 restricts stripe rust growth in wheat. Plant Communications, 2023, 4(5): 100608

20. Li H, Luo J, Zhang W, Hua L, Li K, Wang J, Xu B, Yang C, Wang G, Rouse M, Dubcovsky J#, Chen S#. High-resolution mapping of SrTm4, a recessive resistance gene to wheat stem rust, Theoretical and Applied Genetics, 2023, 136(5): 120

19. Li C, Fan R, Ma C, Zhang Z, … …, Chen S, Zhou Y, Song C, Chen X#, Li H#. Reciprocal translocations hidden by phenotype and genotype within the same wheat cultivar. Crop Science, 2023, 63(5): 2727-2739

18. Huang L, Li Y, Chen S#, Periyannan S#, Fahima Z#, Editorial: Advances in crop resistance breeding using modern genomic tools. Frontiers in Plant Science, 2023, DOI:10.3389/fpls.2023.1143689

17. Ren X, Wang C, Ren Z, Wang J, Zhang P, Zhao S, Chen S#, Wang X#. Genetics of Resistance to Leaf Rust in Wheat: An Overview in a Genome-Wide Level. Sustainability, 2023, 15(4), 3247

16. Bai S, Pang S, Li H, Yang J, Yu H, Chen S#, Wang X#. Broad-Spectrum Resistance to Leaf Rust in the Argentinean Wheat Cultivar “Klein Proteo” Is Controlled by LrKP Located on Chromosome 2BS. Agriculture, 2022, 12(11): 1836

15. Li M, Zhao S, Yang J, Ren Y, ... Chen S, Yu X, Chen F, Wang X. Exogenous expression of barley HvWRKY6 in wheat improves broad-spectrum resistance to leaf rust, Fusarium crown rot, and sharp eyespot. International Journal of Biological Macromolecules, 2022, 218: 1002-1012

14. Jiang D, Hua L, Zhang C, Li H, Wang Z, Li J, ... Dubcovsky J, Chen S#, Mutations in the miRNA165/166 binding site of the HB2 gene result in pleiotropic effects on morphological traits in wheat. The Crop Journal, 2022, 11(1): 9-20 (Cover story)

13. Wang J, Liu H, Zhao C, Tang H, …Chen S, Wei Y, Zheng Y, Lan X, Ma J. Mapping and validation of major and stable QTL for flag leaf size from tetraploid wheat. The Plant Genome, 2022, 15(4), p.e20252

12. Kuzay S, Lin H, Li C, Chen S, Woods DP, Zhang J, Dubcovsky J. WAPO-A1 is the causal gene of the 7AL QTL for spikelet number per spike in wheat. PLoS Genetics, 2022. 18(1): e1009747

11. Luo J, Rouse MN, Hua L, Li H, Li B, Li T, ... Dubcovsky J, Chen S#. Identification and characterization of Sr22b, a new allele of the wheat stem rust resistance gene Sr22 effective against the Ug99 race group, Plant Biotechnology Journal, 2021, 20(3): 554-563

10. Li H, Hua L, Rouse MN, Li T, Pang S, Bai S, Shen T, Luo J, Li H, Zhang W, Wang X, Dubcovsky J, Chen S#, Mapping and characterization of a wheat stem rust resistance gene in durum wheat "Kronos". Frontiers in Plant Science, 2021, 12: 751398

9. Su J, Zhao J, Zhao S, Li M, Pang S, Kang Z, Zhen W, Chen S, Chen F, Wang X, Genetics of Resistance to Common Root Rot (Spot Blotch), Fusarium Crown Rot, and Sharp Eyespot in Wheat. Frontiers in Genetics, 2021, 12: p.699342

8. Chen S*#, Hegarty J, Shen T, Hua L, Li H, Luo J, Li H, Bai S, Zhang C, Dubcovsky J, Stripe rust resistance gene Yr34 (synonym Yr48) is located within a distal translocation of Triticum monococcum chromosome 5AmL into common wheat; Theoretical and Applied Genetics; 2021, 134: 2197-2211

7. Chen S*, Rouse M, Zhang W, Zhang X, Guo Y, Dubcovsky J, Wheat gene Sr60 encodes a protein with two putative kinase domains that confers resistance to stem rust, New Phytologist, 2020, 225: 948–959

6. Chen S*, Zhang W, Stephen B, Rouse M, Dubcovsky J, Identification and characterization of wheat stem rust resistance gene Sr21 effective against Ug99 race group at high temperature, PloS Genetics, 2018, 14(4): e1007287

5. Valentina K, Elitsur Y, Lin H, Dina R, Andrii F, Chen S, Feng L, Frenkel Z, ... Fahima T, Cloning of the wheat Yr15 resistance gene sheds light on the plant tandem kinase-pseudokinase family, Nature Communications, 2018, 9(1): 1-12

4. Chen S*, Yan G, Briggs J, Dubach F, Chao S, Zhang W, Rouse M, Dubcovsky J, Mapping and characterization of wheat stem rust resistance genes SrTm5 and Sr60 from Triticum monococcum, Theoretical and Applied Genetics, 2018, 131.3: 625-635

3. Zhang W*, Chen S*, Abate Z, Nirmala J, Rouse M, and Dubcovsky J, Identification and characterization of Sr13, a tetraploid wheat gene that confers resistance to the Ug99 stem rust race group, Proceedings of the National Academy of Sciences of the United States of America, 2017, 114(45), E9483-E9492

2. Briggs J*, Chen S*, Zhang W, Nelson S, Dubcovsky J, Rouse M, Mapping of SrTm4, a Recessive Stem Rust Resistance Gene from Diploid Wheat Effective to Ug99, Phytopathology, 2015, 105.10: 1347-1354

1. Chen S*, Rouse M, Zhang W, Jin Y, Akhunov E, Wei Y, Dubcovsky J, Fine mapping and characterization of Sr21, a temperature-sensitive diploid wheat resistance gene effective against the Puccinia graminis f. sp. tritici Ug99 race group, Theoretical and Applied Genetics, 2015: 1-12

代表性專利

5. 檢測(cè)小麥Su1-Ph1基因的分子標(biāo)記、部分同源染色體重組小麥的制備方法及應(yīng)用；王桂平,李浩,李洪雨,陳時(shí)盛等；2023112839261

4.小麥葉銹病抗性蛋白及其編碼基因和應(yīng)用；陳時(shí)盛、李洪娜、王桂平等；ZL 2022 1 1247709.2

3.小麥稈銹病抗性蛋白及其編碼基因和應(yīng)用；陳時(shí)盛、李洪娜、華蕾等；ZL 2021 1 0969875.2

2.檢測(cè)小麥抗葉銹病基因Lr47的分子標(biāo)記、檢測(cè)方法及其應(yīng)用；陳時(shí)盛、李洪娜、王桂平等；ZL 2022 1 0114498.9

1.一種檢測(cè)小麥稈銹病抗性基因SrTm5的診斷性分子標(biāo)記及其育種應(yīng)用；陳時(shí)盛、羅靜、華蕾；ZL 2020 1 1374520.0