個(gè)人簡(jiǎn)介

2002年08月-2006年06月，西北農(nóng)林科技大學(xué)，植物保護(hù)學(xué)，學(xué)士（BA）

2006年08月-2012年02月，美國(guó)賓夕法尼亞州立大學(xué) (Penn State University) 植物病理學(xué)，博士（Ph.D.）
2012年03月-2016年08月，美國(guó)馬薩諸塞大學(xué) (UMASS) 生物化學(xué)與分子生物學(xué)系，博士后（Postdoc）
2016年09月-2020年06月，西安交通大學(xué)，電子與信息學(xué)院，副教授 （Associate Professor）
2020年07月-2021年09月，西安交通大學(xué)，電子與信息學(xué)院，教授，博士生導(dǎo)師 （Professor）
2021年10月-至今，北京大學(xué)現(xiàn)代農(nóng)業(yè)研究院，研究員、課題組長(zhǎng)（PI）

榮譽(yù)和獎(jiǎng)勵(lì)

2022年  山東省“泰山學(xué)者”青年專(zhuān)家

2022年  中國(guó)科技期刊卓越行動(dòng)計(jì)劃優(yōu)秀審稿人

2021年  濰坊市“鳶都學(xué)者”

2019年  西安交通大學(xué)第五屆“十大學(xué)術(shù)新人”
2007年  Penn State University Graham Endowed Fellowship 

主要學(xué)術(shù)兼職

Associate Editor for Molecular Plant-Microbe Interactions (Since 2023)

Review Editor for Frontiers in Genetics (Since 2021)

Guest Editor for Plant Physiology and Biochemistry (2022-2023)

研究領(lǐng)域與成果

研究方向聚焦在園藝作物與有害生物的功能基因組學(xué)和表觀轉(zhuǎn)錄調(diào)控、天然產(chǎn)物的生物合成途徑與異源合成、作物病原真菌侵染的化學(xué)生物學(xué)機(jī)制等前沿科學(xué)技術(shù)問(wèn)題，以及相關(guān)實(shí)驗(yàn)計(jì)算方法的開(kāi)發(fā)和數(shù)據(jù)庫(kù)的搭建，為作物分子育種、食品安全、制藥等領(lǐng)域提供理論和技術(shù)支撐。研究?jī)?nèi)容包括三個(gè)方面：

1.    作物基因組學(xué)與多組學(xué)：開(kāi)展園藝作物的結(jié)構(gòu)、功能和進(jìn)化基因組學(xué)研究，深度挖掘作物多組學(xué)數(shù)據(jù)，鑒定作物優(yōu)良性狀基因，指導(dǎo)分子設(shè)計(jì)育種；

2.    植物天然產(chǎn)物的生物合成：研究藥用植物重要天然活性產(chǎn)物的生物合成途徑、調(diào)控機(jī)制、生物制造；

3.    植物-微生物互作的化學(xué)生物學(xué)：研究植物病原真菌次生代謝基因簇的功能和調(diào)控機(jī)制，指導(dǎo)作物真菌病害防治。

研究成果已發(fā)表SCI論文36篇，以第一作者或通訊作者身份在Science、PNAS、Nature Communications、New Phytologist、Horticulture Research等多個(gè)國(guó)際著名期刊上發(fā)表SCI論文20篇，參與編寫(xiě)專(zhuān)著3部，申請(qǐng)獲批國(guó)家發(fā)明專(zhuān)利5項(xiàng)；研究成果被Nature, Science, Cell等國(guó)際著名期刊引用過(guò)百次；主持國(guó)家自然科學(xué)基金委面上項(xiàng)目、青年項(xiàng)目、國(guó)家人社部高層次留學(xué)回國(guó)人員資助項(xiàng)目，以課題骨干身份參與國(guó)家重點(diǎn)研發(fā)項(xiàng)目子課題1項(xiàng)；為多個(gè)國(guó)際權(quán)威期刊審稿150余次，被評(píng)為2022年度中國(guó)科技期刊卓越行動(dòng)計(jì)劃優(yōu)秀審稿人。
 

代表性論文

 (*: Co-first author; #: Corresponding author)

      1.   Liu H, Wang H, Liao XL, Gao B, Lu X, Sun D, Gong W, Zhong J, Zhu H, Pan X, Guo L#, Deng XW# and Zhou Q#. (2022) Mycoviral gene integration converts a plant pathogenic fungus into a biocontrol agent. Proc Natl Acad Sci USA. 119(50): e2214096119

      2.   Guo L*#, Yao Hui*, Chen W*, Wang X, Ye P, Xu Z, Zhang S,Wu H#. (2022) Natural products of medicinal Plants: biosynthesis and bioengineering in post-genomic era, Horticulture Research. Vol.9: uhac223.

      3.   Wang J*, Li J*#, Li Z, Liu B, Zhang L, Guo D, Huang S, Qian W# , Guo L#. (2022) Genomic insights into longan evolution from a chromosome-level genome assembly and population genomics of longan accessions. Horticulture Research. Vol. 9: uhac021.

      4.   Yang X*, Gao S*, Guo L*, Wang B, Jia Y, Zhou J, Che Y, Jia P, Lin J, Xu T, Sun J, Ye K#. (2021) Three chromosome-scale Papaver genomes reveal punctuated patchwork evolution of the morphinan and noscapine biosynthesis pathway. Nature Communications. 12:6030.

      5.   Guo L*, Winzer T*, Yang X*, Li Y*, Ning Z*, He Z, Teodor R, Lu Y, Bowser TA, Graham IA#, Ye K#. (2018) The opium poppy genome and morphinan production. Science. 362(6412): p. 343-347.

      6.   Kang Y*, Ji X*, Guo L*, Xia H*, Yang X, Xie Z, Shi X, Wu R, Feng D, Wang C, Chen M, Zhang W, Wei H, Guan Y, Ye K#, Zhao G#. (2021) Cerebrospinal fluid from healthy pregnant women does not harbor a detectable microbial community. Microbiology Spectrum. 9(3): e00769-21.

      7.   Guo L, Ye K#. (2019) Mapping genome variants sheds light on genetic and phenotypic differentiation in Chinese. Genomics, Proteomics & Bioinformatics. 17(3): p226-228

      8.   Guo L, Zhao G, Gao L, Xu JR, Kistler HC, Ma LJ#. (2016) Compartmentalized gene regulatory network of a pathogenic fungus Fusarium graminearum. New Phytologist. 211(2): 527-541.

      9.   Guo L*, Yu H*, Wang B*, Vescio K, Delulio G, Yang H, Berg A, Zhang L, Edel-Hermann V, Steinberg C, Kistler HC, Ma LJ#. (2021) Metatranscriptomic comparison of endophytic and pathogenic Fusarium-Arabidopsis interactions reveals plant transcriptional plasticity. Molecular Plant-Microbe Interactions. 34(9):1071-1083

      10.  Jia Y, Chen S, Chen W, Zhang P, Su Z, Zhang L, Xu M and Guo L#. (2022) A chromosome-level reference genome of Chinese balloon flower (Platycodon grandiflorus). Frontiers in Genetics. 13:869784.

      11.  Wang B, Yu H, Jia Y, Dong Q, Steinberg C, Alabouvette CL, Edel-Hermann V, Kistler HC, Ye K#, Ma LJ#, and Guo L#. (2020) Chromosome-scale genome assembly of strain Fo47, a fungal endophyte and biocontrol agent. Molecular Plant-Microbe Interactions. 33(9):1108-1111

      12.  Wang B*, Guo L*, Ye K#, Wang L#. (2020) Chromosome-scale genome assembly of Talaromyces rugulosus strain W13939, a mycoparasitic fungus and promising biocontrol agent. Molecular Plant-Microbe Interactions. 33(12):1446-1450.

      13.  Shao C*, Xiang D*, Wei H*, Liu S, Yi G, Lyu S#, Guo L#, Li C#. (2020) Predicting virulence of Fusarium oxysporum f. sp. cubense based on the production of mycotoxin using a linear regression model. Toxins. 12: 254.

      14.  Xu T, Yang X, Jia Y, Li Z, Tang G, Li X, Wang B, Wang T, Lin J, Guo L, Ye K#. (2022) A global survey of the transcriptome of the opium poppy (Papaver somniferum) based on single-molecule long-read isoform sequencing. The Plant Journal. 110: 607-620.

      15.  Guo L*#, Ji M*, and Ye K#. (2020) Dynamic network inference and association computation discover gene modules regulating virulence, mycotoxin production and sexual reproduction in Fusarium graminearum. BMC Genomics. 21:179

      16.  Chaisson, M.J.P.*, A.D. Sanders*, X. Zhao*, A. Malhotra, D. Porubsky, T. Rausch, E.J. Gardner, O. Rodriguez, Guo L, R.L. Collins, X. Fan, J. Wen, R.E. Handsaker, S. Fairley, Z.N. Kronenberg, X. Kong, F. Hormozdiari, D. Lee, A.M. Wenger, A. Hastie, D. Antaki, P. Audano, H. Brand, S. Cantsilieris, H. Cao, E. Cerveira, C. Chen, X. Chen, C.-S. Chin, Z. Chong, N.T. Chuang, C.C. Lambert, D.M. Church, L. Clarke, A. Farrell, J. Flores, T. Galeev, D. Gorkin, M. Gujral, V. Guryev, W. Haynes Heaton, J. Korlach, S. Kumar, J.Y. Kwon, J.E. Lee, J. Lee, W.-P. Lee, S.P. Lee, S. Li, P. Marks, K. Viaud-Martinez, S. Meiers, K.M. Munson, F. Navarro, B.J. Nelson, C. Nodzak, A. Noor, S. Kyriazopoulou-Panagiotopoulou, A. Pang, Y. Qiu, G. Rosanio, M. Ryan, A. Stutz, D.C.J. Spierings, A. Ward, A.E. Welch, M. Xiao, W. Xu, C. Zhang, Q. Zhu, X. Zheng-Bradley, E. Lowy, S. Yakneen, S. McCarroll, G. Jun, L. Ding, C.L. Koh, B. Ren, P. Flicek, K. Chen, M.B. Gerstein, P.-Y. Kwok, P.M. Lansdorp, G. Marth, J. Sebat, X. Shi, A. Bashir, K. Ye, S.E. Devine, M. Talkowski, R.E. Mills, T. Marschall, J.O. Korbel#, E.E. Eichler#, and C. Lee#. (2019) Multi-platform discovery of haplotype-resolved structural variation in human genomes. Nature Communications. 10:1784

      17.  Guo L, Breakspear A, Zhao G, Gao L, Kistler HC, Xu JR, Ma LJ#. (2016) Conservation and divergence of the cyclic adenosine monophosphate–protein kinase A (cAMP–PKA) pathway in two plant-pathogenic fungi: Fusarium graminearum and F.?verticillioides. Molecular Plant Pathology 17(2): 196-209.

      18.  Guo L, Allen KS, Deiulio GA, Zhang Y, Wick RL, Ma LJ#. (2016) A de-novo-assembly-based pipeline for data mining in plant obligate parasite metatranscriptomic studies. Frontiers in Plant Science. 7: 925